Responses to the comments of Todd Abel on behalf of the Chlorine Chemistry Division of the American Chemistry Council
نویسنده
چکیده
OEHHA is proposing to replace the Toxicity Equivalency Factors (TEF), which were developed by the World Health Organization (WHO) in 1997, with the more recent TEF values developed by the WHO in 2005. We agree with and support this revision. As noted correctly by OEHHA, the TEF methodology has evolved and improved over the years as additional toxicological data became available. The adoption of the WHO 2005 TEF values is a logical and laudable step in the direction of improving the TEF methodology. Although it is widely acknowledged that there are a number of limitations of the TEF methodology, it provides a useful tool for the health risk assessment of dioxins and dioxin-like compounds. The TEF approach is particularly valuable for screening risk assessment and as an interim approach to risk assessment until more appropriate data become available.
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